Get to know and reach out to the experts at Profil.

Short Bio

Sabine has worked in diabetes for more than 20 years with a background in both academia and 9 years pharmaceutical industry. Since 2003 she has been Principal Investigator for phase 1 PK/PD trials, clamp trials and the German PI for the artifical pancreas trials (AP@Home).

Major Scientific Contributions

Sabine has been working in diabetes since 1989, starting with Professor Michael Berger’s group at the Clinic of Metabolic Diseases and Nutrition, Heinrich-Heine University hospital, Duesseldorf, where she worked for several years. Afterwards she was with Novo Nordisk for 9 years, being responsible for quite a number of clinical trials in Germany, Austria and Switzerland, especially short- and long-acting insulin analogue, and inhaled insulin trials. Sabine joined her former University colleagues Prof. Lutz Heinemann and Dr Tim Heise at Profil in 2003. She has been Principal Investigator for several clinical phase I PK/PD and glucose clamp trials with new antidiabetic compounds.

Publications

Here are Sabine's recent publications: 

• Dovc K, Boughton C, Tauschmann M, Thabit H, Bally L, Allen JM, Acerini CL, Arnolds S, de Beaufort C, Bergenstal RM, Criego A, Dunger DB, Elleri D, Evans ML, Fröhlich-Reiterer E, Hofer S, Kapellen T, Leelarathna L, Pieber TR, Rami-Merhar B, Shah VN, Sibayan J, Wilinska ME, Hovorka R; APCam11, AP@Home, and KidsAP Consortia.
  Young children have higher variability of insulin requirements: Observations during hybrid closed-loop insulin delivery.
  DIABETES CARE 42: 1344-137, 2019 
• Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R.
  Evaluating glucose control with a novel composite continuous glucose monitoring index.
  J DIABETES SCI TECHNOL 2019 MAR 31. doi: 10.1177/1932296819838525. (Epub ahead of print)
• Ruan Y, Bally L, Thabit H, Leelarathna L, Hartnell S, Tauschmann M, Wilinska ME, Evans ML, Kojzar H, Dellweg S, Benesch C, Arnolds S, Pieber TR, Hovorka R.
  Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes.
  DIABETES OBES METAB 2018 Mar 25. doi: 10.1111/dom.13304. (Epub ahead of print)
• Bally L, Thabit H, Ruan Y, Mader JK, Kojzar H, Dellweg S, Benesch C, Hartnell S, Leelarathna L, Wilinska ME, Evans ML, Arnolds S, Pieber TR, Hovorka R.
  Bolusing frequency and amount impacts glucose control during hybrid closed-loop.
  DIABET MED 2017 Jul 29. doi: 10.1111/dme.13436. (Epub ahead of print)
• Emami A, Wilinska ME, Thabit H, Leelarathna L, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Pieber TR, Arnolds S, Evans ML, Hovorka R.
  Behavioral patterns and associations with glucose control during 12-week randomized free-living clinical trial of day and night hybrid closed-loop insulin delivery in adults with type 1 diabetes.
  DIABETES TECHNOL THER 2017 May 2. doi: 10.1089/dia.2016.0307. (Epub ahead of print)
• Barnard KD, Wysocki T, Ully V, Mader JK, Pieber TR, Thabit H, Tauschmann M, Leelarathna L, Hartnell S, Acerini CL, Wilinska ME, Dellweg S, Benesch C, Arnolds S, Holzer M, Kojzar H, Campbell F, Yong J, Picchierri J, Hindmarsh P, Heinemann L, Evans ML, Hovorka R.
  Closing the loop in adults, children and adolescents with suboptimally controlled type 1 diabetes under free living conditions: A psychosocial substudy.
  J DIABETES SCI TECHNOL 2017 Apr 1. doi: 10.1177/1932296817702656. (Epub ahead of print)
• Ruan Y, Thabit H, Leelarathna L, Hartnell S, Wilinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R on behalf of AP@home consortium.
  Faster insulin action is associated with improved outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.
  DIABETES OBES METAB 2017. doi: 10.1111/dom.12956 (Epub ahead of print)
• Leelarathna L, Thabit H, Hartnell S, Wilinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, on behalf of the AP@home Consortium.
  Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes.
  J DIABETES SCI TECHNOL 11: 180-181, 2017
• Ruan Y, Thabit H, Leelarathna L, Hartnell S, Wilinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R, on behalf of the AP@home Consortium.
  Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes.
  DIABETES CARE 39: 830-832, 2016
• Thabit H, Tauschmann M, Allen JM, Leelarathna L, Hartnell S, Wilinska ME, Acerini CL, Dellweg S, Benesch C, Heinemann L, Mader JK, Holzer M, Kojzar H, Exall J, Yong J, Pichierri J, Barnard KD, Kollman C, Cheng P, Hindmarsh PC, Campbell FM, Arnolds S, Pieber TR, Evans ML, Dunger DB, Hovorka R; APCam Consortium and AP@home Consortium.
  Home use of an artificial beta cell in type 1 diabetes
  N ENGL J MED 2015 Sep 17. doi: 10.1056/NEJMoa1509351. (Epub ahead of print)
• Thabit H, Leelarathna L, Wilinska ME, Elleri D, Allen JM, Lubina-Solomon A, Walkinshaw E, Stadler M, Choudhary P, Mader JK, Dellweg S, Benesch C, Pieber TR, Arnolds S, Heller SR, Amiel SA, Dunger D, Evans ML, Hovorka R.
  Accuracy of continuous glucose monitoring during three closed-loop home studies under free-living conditions.
  DIABETES TECHNOL THER 17: 801-807, 2015
• Benesch C, Heise T, Klein O, Heinemann L, Arnolds S.
  How to assess the quality of glucose clamps? Evaluation of clamps performed with ClampArt, a novel automated clamp device.
  J DIABETES SCI TECHNOL 9: 792-800, 2015.
• Arnolds S, Heckermann S, Heise T, Sawicki PT.
  Spectrum of diabetes research does not reflect patients`scientific preferences: A longitudinal evaluation of diabetes research areas 2010-2013 vs. a cross-sectional survey in patients with diabetes.
  EXP CLIN ENDOCRINOL DIABETES 123: 299-302, 2015.
• Arnolds S, Sawicki PT.
  Comment on Retnakaran et al. Liraglutide and the preservation of pancreatic beta-cell function in early type 2 diabetes: the LIBRA trial. Diabetes Care 2014;37:3270-3278.
  DIABETS CARE 2015 Feb; 38(2):e25. doi: 10.2337/dc14-2418.
• Leelarathna L, Dellweg S, Mader JK, Allen JM, Benesch C, Doll W, Ellmerer M, Hartnell S, Heinemann L, Kojzar H, Michalewski L, Nodale M, Thabit H, Wilinska ME, Pieber TR, Arnolds S, Evans ML, Hovorka R, on behalf of the AP@home Consortium.
  Day and night home closed-loop insulin delivery in adults with type 1 diabetes: three-center randomized crossover study.
  DIABETES CARE 37: 1931-1937, 2014
• Arnolds S, Heise T, Flacke F, Sieber J.
  Common standards of basal insulin titration in T2DM.
  J DIABETES SCI TECHNOL 7: 771-788, 2013
• Luijf YM, Arnolds S, Avogaro A, Benesch C, Bruttomesso D, Farret A, Heinemann L, Place J, Renard E, Scotton R, DeVries JH, on behalf of the AP@home consortium.
  Patch pump versus conventional pump: Postprandial glycemic excursions and the influence of wear time.
  DIABETES TECHNOL THER 15: 575-579, 2013
• Luijf YM, Mader JK, Doll W, Pieber T, Farret A, Place J, Renard E, Bruttomesso D, Filippi A, Avogaro A, Arnolds S, Benesch C, Heinemann L, DeVries JH, on behalf of the AP@home consortium.
  Accuracy and reliability of continuous glucose monitoring systems: a head-to-head comparison.
  DIABETES TECHNOL THER 15: 722-727, 2013
• Luijf YM, DeVries JH, Zwinderman K, Leerathna L, Nodale M, Caldwell K, Kumareswaran K, Elleri D, Allen JM, Wilinska ME, Evans ML, Hovorka R, Doll W, Ellmerer M, Mader JK, Renard E, Place J, Farret A, Cobelli C, Del Favero S, Dalla Man C, Avogaro A, Bruttomesso D, Filippi A, Scotton R, Magni L, Lanzola G, Di Palma F, Toffanin C, Arnolds S, Benesch C, Heinemann L, on behalf of the AP@home consortium.
  Day and night closed-loop control in adults with type 1 diabetes mellitus.
  DIABETES CARE 36: 3882-3887, 2013
• Nosek L, Roggen K, Heinemann L, Gottschalk C, Kaiser M, Arnolds S, Heise T.
  Insulin aspart has a shorter duration of action than human insulin over a wide dose-range.
  DIABETES OBES METAB 15: 77-83, 2013
• Arnolds S, Heckermann S, Koch C, Heissmann N, Sawicki PT.
  How do patients' Exp Clin Endocrinol Diabetespreferences compare to the present spectrum of diabetes research?
   EXP CLIN ENDOCRINOL DIABETES 121(1): 60-63, 2013

Browse Profil's list of publications to see our other publications.

Selected Achievements and Work Experience