认识和联系Profil的专家

简介

Sabine在糖尿病领域工作了20多年，她具有学术界以及9年在制药行业的背景。自2003年以来，她一直担任I期PK/PD试验、钳夹试验的首席研究员以及人工胰腺试验 (AP@Home) 的德国首席研究员。

主要科学成就

Sabine自1989年以来一直从事糖尿病研究工作，从杜塞尔多夫海因里希海涅大学医院代谢疾病与营养诊所的Michael Berger教授小组开始，她在该医院工作了数年。 之后她在诺和诺德（Novo Nordisk）工作了9年，负责德国、奥地利和瑞士的多项临床试验，尤其是短效和长效胰岛素类似物以及吸入式胰岛素试验。2003年，Sabine加入了她的大学同事Tim Heise博士和Lutz Heinemann教授所在的Profil。她曾在多个使用新型抗糖尿病化合物进行的临床I期PK/PD以及葡萄糖钳夹试验中担任首席研究员。

发表物

以下是Sabine的近期发表物: 

• Dovc K, Boughton C, Tauschmann M, Thabit H, Bally L, Allen JM, Acerini CL, Arnolds S, de Beaufort C, Bergenstal RM, Criego A, Dunger DB, Elleri D, Evans ML, Fröhlich-Reiterer E, Hofer S, Kapellen T, Leelarathna L, Pieber TR, Rami-Merhar B, Shah VN, Sibayan J, Wilinska ME, Hovorka R; APCam11, AP@Home, and KidsAP Consortia.
  Young children have higher variability of insulin requirements: Observations during hybrid closed-loop insulin delivery.
  DIABETES CARE 42: 1344-137, 2019 
• Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R.
  Evaluating glucose control with a novel composite continuous glucose monitoring index.
  J DIABETES SCI TECHNOL 2019 MAR 31. doi: 10.1177/1932296819838525. (Epub ahead of print)
• Ruan Y, Bally L, Thabit H, Leelarathna L, Hartnell S, Tauschmann M, Wilinska ME, Evans ML, Kojzar H, Dellweg S, Benesch C, Arnolds S, Pieber TR, Hovorka R.
  Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes.
  DIABETES OBES METAB 2018 Mar 25. doi: 10.1111/dom.13304. (Epub ahead of print)
• Bally L, Thabit H, Ruan Y, Mader JK, Kojzar H, Dellweg S, Benesch C, Hartnell S, Leelarathna L, Wilinska ME, Evans ML, Arnolds S, Pieber TR, Hovorka R.
  Bolusing frequency and amount impacts glucose control during hybrid closed-loop.
  DIABET MED 2017 Jul 29. doi: 10.1111/dme.13436. (Epub ahead of print)
• Emami A, Wilinska ME, Thabit H, Leelarathna L, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Pieber TR, Arnolds S, Evans ML, Hovorka R.
  Behavioral patterns and associations with glucose control during 12-week randomized free-living clinical trial of day and night hybrid closed-loop insulin delivery in adults with type 1 diabetes.
  DIABETES TECHNOL THER 2017 May 2. doi: 10.1089/dia.2016.0307. (Epub ahead of print)
• Barnard KD, Wysocki T, Ully V, Mader JK, Pieber TR, Thabit H, Tauschmann M, Leelarathna L, Hartnell S, Acerini CL, Wilinska ME, Dellweg S, Benesch C, Arnolds S, Holzer M, Kojzar H, Campbell F, Yong J, Picchierri J, Hindmarsh P, Heinemann L, Evans ML, Hovorka R.
  Closing the loop in adults, children and adolescents with suboptimally controlled type 1 diabetes under free living conditions: A psychosocial substudy.
  J DIABETES SCI TECHNOL 2017 Apr 1. doi: 10.1177/1932296817702656. (Epub ahead of print)
• Ruan Y, Thabit H, Leelarathna L, Hartnell S, Wilinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R on behalf of AP@home consortium.
  Faster insulin action is associated with improved outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.
  DIABETES OBES METAB 2017. doi: 10.1111/dom.12956 (Epub ahead of print)
• Leelarathna L, Thabit H, Hartnell S, Wilinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, on behalf of the AP@home Consortium.
  Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes.
  J DIABETES SCI TECHNOL 11: 180-181, 2017
• Ruan Y, Thabit H, Leelarathna L, Hartnell S, Wilinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R, on behalf of the AP@home Consortium.
  Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes.
  DIABETES CARE 39: 830-832, 2016
• Thabit H, Tauschmann M, Allen JM, Leelarathna L, Hartnell S, Wilinska ME, Acerini CL, Dellweg S, Benesch C, Heinemann L, Mader JK, Holzer M, Kojzar H, Exall J, Yong J, Pichierri J, Barnard KD, Kollman C, Cheng P, Hindmarsh PC, Campbell FM, Arnolds S, Pieber TR, Evans ML, Dunger DB, Hovorka R; APCam Consortium and AP@home Consortium.
  Home use of an artificial beta cell in type 1 diabetes
  N ENGL J MED 2015 Sep 17. doi: 10.1056/NEJMoa1509351. (Epub ahead of print)
• Thabit H, Leelarathna L, Wilinska ME, Elleri D, Allen JM, Lubina-Solomon A, Walkinshaw E, Stadler M, Choudhary P, Mader JK, Dellweg S, Benesch C, Pieber TR, Arnolds S, Heller SR, Amiel SA, Dunger D, Evans ML, Hovorka R.
  Accuracy of continuous glucose monitoring during three closed-loop home studies under free-living conditions.
  DIABETES TECHNOL THER 17: 801-807, 2015
• Benesch C, Heise T, Klein O, Heinemann L, Arnolds S.
  How to assess the quality of glucose clamps? Evaluation of clamps performed with ClampArt, a novel automated clamp device.
  J DIABETES SCI TECHNOL 9: 792-800, 2015.
• Arnolds S, Heckermann S, Heise T, Sawicki PT.
  Spectrum of diabetes research does not reflect patients`scientific preferences: A longitudinal evaluation of diabetes research areas 2010-2013 vs. a cross-sectional survey in patients with diabetes.
  EXP CLIN ENDOCRINOL DIABETES 123: 299-302, 2015.
• Arnolds S, Sawicki PT.
  Comment on Retnakaran et al. Liraglutide and the preservation of pancreatic beta-cell function in early type 2 diabetes: the LIBRA trial. Diabetes Care 2014;37:3270-3278.
  DIABETS CARE 2015 Feb; 38(2):e25. doi: 10.2337/dc14-2418.
• Leelarathna L, Dellweg S, Mader JK, Allen JM, Benesch C, Doll W, Ellmerer M, Hartnell S, Heinemann L, Kojzar H, Michalewski L, Nodale M, Thabit H, Wilinska ME, Pieber TR, Arnolds S, Evans ML, Hovorka R, on behalf of the AP@home Consortium.
  Day and night home closed-loop insulin delivery in adults with type 1 diabetes: three-center randomized crossover study.
  DIABETES CARE 37: 1931-1937, 2014
• Arnolds S, Heise T, Flacke F, Sieber J.
  Common standards of basal insulin titration in T2DM.
  J DIABETES SCI TECHNOL 7: 771-788, 2013
• Luijf YM, Arnolds S, Avogaro A, Benesch C, Bruttomesso D, Farret A, Heinemann L, Place J, Renard E, Scotton R, DeVries JH, on behalf of the AP@home consortium.
  Patch pump versus conventional pump: Postprandial glycemic excursions and the influence of wear time.
  DIABETES TECHNOL THER 15: 575-579, 2013
• Luijf YM, Mader JK, Doll W, Pieber T, Farret A, Place J, Renard E, Bruttomesso D, Filippi A, Avogaro A, Arnolds S, Benesch C, Heinemann L, DeVries JH, on behalf of the AP@home consortium.
  Accuracy and reliability of continuous glucose monitoring systems: a head-to-head comparison.
  DIABETES TECHNOL THER 15: 722-727, 2013
• Luijf YM, DeVries JH, Zwinderman K, Leerathna L, Nodale M, Caldwell K, Kumareswaran K, Elleri D, Allen JM, Wilinska ME, Evans ML, Hovorka R, Doll W, Ellmerer M, Mader JK, Renard E, Place J, Farret A, Cobelli C, Del Favero S, Dalla Man C, Avogaro A, Bruttomesso D, Filippi A, Scotton R, Magni L, Lanzola G, Di Palma F, Toffanin C, Arnolds S, Benesch C, Heinemann L, on behalf of the AP@home consortium.
  Day and night closed-loop control in adults with type 1 diabetes mellitus.
  DIABETES CARE 36: 3882-3887, 2013
• Nosek L, Roggen K, Heinemann L, Gottschalk C, Kaiser M, Arnolds S, Heise T.
  Insulin aspart has a shorter duration of action than human insulin over a wide dose-range.
  DIABETES OBES METAB 15: 77-83, 2013
• Arnolds S, Heckermann S, Koch C, Heissmann N, Sawicki PT.
  How do patients' Exp Clin Endocrinol Diabetespreferences compare to the present spectrum of diabetes research?
   EXP CLIN ENDOCRINOL DIABETES 121(1): 60-63, 2013

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主要成就及工作经验