Get to know and reach out to the experts at Profil.




Dr. Tim Heise
Lead Scientist

Tim is the Co-founder and Lead Scientist of Profil. He is your contact partner, among others, for the following areas:

  • Insulin analogues
  • Pharmacodynamics
  • Clinical development consulting services

Short Bio

Tim has more than 25 years of experience in both clinical research and clinical care in diabetes and obesity. He has published well over 250 scientific papers and reviews with a focus on the pharmacology of insulin and anti-diabetic drugs. Dr Heise is a member of the Editorial Board for Diabetes, Obesity and Metabolism and he takes a strong interest in evidence-based medicine.


Here are Tim's recent publications:

Browse Profil's list of publications to see our other publications.


Selected Achievements and Work Experience

2016 - 

Lead Scientist and chair of the Board of Directors of Profil. 

1999 - 2016

Co-founder and CEO Science of Profil. Principal Investigator of several hundred challenging early phase studies of experimental diabetes treatments; in particular pharmacodynamic / pharmacokinetic assessments performed with the glucose clamp technique


Co-founder of DIEM, Institute for Evidence-Based Medicine in Cologne, Germany

2000 - 2002

Clinical job on the side at the Department for Internal Medicine, St. Franziskus Hospital Cologne (Director: Prof. P.T. Sawicki) for the outpatient care of diabetic patients

1991 - 1999

Scientific Associate, Clinic of Metabolic Diseases and Nutrition, Heinrich-Heine-University Düsseldorf, WHO Collaborating Center for Diabetes. Occupation at the Diabetes ward and the Endocrinology/Rheumatology ward, the out-patient clinics for diabetes, diabetic foot problems, diabetic late complications, and obesity, and at the Intensive Care Unit. In charge of numerous GCP-studies concerning insulin resistance, hypertension, obesity, and pharmacokinetic and –dynamic properties of novel insulin preparations, insulin administration forms and antidiabetic drugs