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Dr. Marc Stoffel
Scientific Study Advisor

Marc is a physician specialized in clinical pharmacology with more than 10 years of experience in early drug development and is your contact partner, among others, for the following area:

Drug-Drug interaction
Membrane transport proteins
Cocktail studies

Short Bio

Marc joined Profil in 2017 and has worked in the fields of pathology, anesthesiology and internal medicine before he returned to academia, where he dedicated his work to the characterization of membrane transport proteins. His experience comprises both molecular biological in vitro experiments and the planning and conduction of all kinds of early clinical studies in vivo. Marc contributes with his expertise to set up clinical studies in the project development team.

Publications

Here are Marc's recent publications:

Hsin CH, Stoffel MS, Gazzaz M, Schaeffeler E, Schwab M, Fuhr U, Taubert M.
Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.
Sci Rep. 2020 Jul 27;10(1):12457. doi: 10.1038/s41598-020-69326-y. PMID: 32719417; PMCID: PMC7385621.
Trueck C, Hsin CH, Scherf-Clavel O, Schaeffeler E, Lenssen R, Gazzaz M, Gersie M, Taubert M, Quasdorff M, Schwab M, Kinzig M, Sörgel F, Stoffel MS, Fuhr U. A
Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.
Clin Pharmacol Ther. 2019 Dec;106(6):1398-1407. doi: 10.1002/cpt.1564. Epub 2019 Aug 12. PMID: 31247117.
Scherf-Clavel O, Kinzig M, Stoffel MS, Fuhr U, Sörgel F. A
HILIC-MS/MS assay for the quantification of metformin and sitagliptin in human plasma and urine: A tool for studying drug transporter perturbation.
J Pharm Biomed Anal. 2019 Oct 25;175:112754. doi: 10.1016/j.jpba.2019.07.002. Epub 2019 Jul 3. PMID: 31336285.
Scherf-Clavel O, Kinzig M, Stoffel MS, Fuhr U, Sörgel F.
Quantification of adefovir and pitavastatin in human plasma and urine by LC-MS/MS: A useful tool for drug-drug interaction studies.
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121718. doi: 10.1016/j.jchromb.2019.121718. Epub 2019 Jul 16. PMID: 31330406.
Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X, Taubert M, Trueck C, Iltgen-Breburda J, Kraus D, Queckenberg C, Stoffel M, Schwab M, Sörgel F, Fuhr U.
Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?
Clin Pharmacol Ther. 2018 Dec;104(6):1249-1259. doi: 10.1002/cpt.1083. Epub 2018 May 10. PMID: 29633238.
von Bergwelt-Baildon MS, Popov A, Saric T, Chemnitz J, Classen S, Stoffel MS, Fiore F, Roth U, Beyer M, Debey S, Wickenhauser C, Hanisch FG, Schultze JL.
CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
Blood. 2006 Jul 1;108(1):228-37. doi: 10.1182/blood-2005-08-3507. Epub 2006 Mar 7. PMID: 16522817.
Wickenhauser C, Thiele J, Pérez F, Varus E, Stoffel MS, Kvasnicka HM, Beelen DW, Schaefer UW.
Mixed chimerism of the resident macrophage population after allogeneic bone marrow transplantation for chronic myeloid leukemia.
Transplantation. 2002 Jan 15;73(1):104-11. doi: 10.1097/00007890-200201150-00020. PMID: 11792988.

Browse Marc's entire list of publications or Profil's recent list of publications to see our other publications.

Selected Achievements and Work Experience

2017 -	Scientific Study Advisor at Profil
2016	Board certification in Clinical pharmacology
2014 - 2017	Physician scientist at the Centre for Pharmacology, University Hospital Cologne, Cologne, Germany
2014	Project manager at the Department of Clinical Chemistry and Pharmacology, University of Bonn Medical Centre, Bonn, Germany
2011 - 2013	Study physician at the Department of Clinical Pharmacology of MEDA Manufacturing GmbH, ‘ClinPharmCologne’, Cologne, Germany
2011 -	Investigator and sub-investigator in numerous GCP-studies including cardiovascular, hypertension, hemostaseology, hematology and oncology, infection and inflammation, insulin resistance, obesity, pharmacokinetic and-dynamic properties of novel insulin preparations, insulin administration forms, and antidiabetic drugs; Phase I-IV
2005 - 2009	Resident at the Department of Internal Medicine, St. Bernhard Hospital, Brake, Germany; Resident at the Department of Anesthesiology, Merheim Hospital, Cologne, Germany; Scientific Associate at the Institute for Pathology, University Hospital Cologne, Cologne, Germany
2005	Doctorate at the University of Cologne (Institute for Pathology, Prof. Dr. J. Thiele)