认识和联系Profil的专家
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Marc Stoffel 博士
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简介
Marc于2017年加入Profil。在回到学术界之前，他曾在病理学、麻醉学以及内科等领域工作，致力于跨膜运输蛋白的特征研究。他的经验包括分子生物学体外实验，以及各种体内早期临床研究的规划和实施。Marc以他的专业知识为项目开发团队开展临床研究做出了贡献。
发表物
以下是Marc的近期发表物:
- Hsin CH, Stoffel MS, Gazzaz M, Schaeffeler E, Schwab M, Fuhr U, Taubert M.
Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.
Sci Rep. 2020 Jul 27;10(1):12457. doi: 10.1038/s41598-020-69326-y. PMID: 32719417; PMCID: PMC7385621. - Trueck C, Hsin CH, Scherf-Clavel O, Schaeffeler E, Lenssen R, Gazzaz M, Gersie M, Taubert M, Quasdorff M, Schwab M, Kinzig M, Sörgel F, Stoffel MS, Fuhr U. A
Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.
Clin Pharmacol Ther. 2019 Dec;106(6):1398-1407. doi: 10.1002/cpt.1564. Epub 2019 Aug 12. PMID: 31247117. - Scherf-Clavel O, Kinzig M, Stoffel MS, Fuhr U, Sörgel F. A
HILIC-MS/MS assay for the quantification of metformin and sitagliptin in human plasma and urine: A tool for studying drug transporter perturbation.
J Pharm Biomed Anal. 2019 Oct 25;175:112754. doi: 10.1016/j.jpba.2019.07.002. Epub 2019 Jul 3. PMID: 31336285. - Scherf-Clavel O, Kinzig M, Stoffel MS, Fuhr U, Sörgel F.
Quantification of adefovir and pitavastatin in human plasma and urine by LC-MS/MS: A useful tool for drug-drug interaction studies.
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121718. doi: 10.1016/j.jchromb.2019.121718. Epub 2019 Jul 16. PMID: 31330406. - Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X, Taubert M, Trueck C, Iltgen-Breburda J, Kraus D, Queckenberg C, Stoffel M, Schwab M, Sörgel F, Fuhr U.
Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?
Clin Pharmacol Ther. 2018 Dec;104(6):1249-1259. doi: 10.1002/cpt.1083. Epub 2018 May 10. PMID: 29633238. - von Bergwelt-Baildon MS, Popov A, Saric T, Chemnitz J, Classen S, Stoffel MS, Fiore F, Roth U, Beyer M, Debey S, Wickenhauser C, Hanisch FG, Schultze JL.
CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
Blood. 2006 Jul 1;108(1):228-37. doi: 10.1182/blood-2005-08-3507. Epub 2006 Mar 7. PMID: 16522817. - Wickenhauser C, Thiele J, Pérez F, Varus E, Stoffel MS, Kvasnicka HM, Beelen DW, Schaefer UW.
Mixed chimerism of the resident macrophage population after allogeneic bone marrow transplantation for chronic myeloid leukemia.
Transplantation. 2002 Jan 15;73(1):104-11. doi: 10.1097/00007890-200201150-00020. PMID: 11792988.
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主要成就及工作经验
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2017 - |
Scientific Study Advisor at Profil |
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2016 |
Board certification in Clinical pharmacology |
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2014 - 2017 |
Physician scientist at the Centre for Pharmacology, University Hospital Cologne, Cologne, Germany |
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2014 |
Project manager at the Department of Clinical Chemistry and Pharmacology, University of Bonn Medical Centre, Bonn, Germany |
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2011 - 2013 |
Study physician at the Department of Clinical Pharmacology of MEDA Manufacturing GmbH, ‘ClinPharmCologne’, Cologne, Germany |
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2011 - |
Investigator and sub-investigator in numerous GCP-studies including cardiovascular, hypertension, hemostaseology, hematology and oncology, infection and inflammation, insulin resistance, obesity, pharmacokinetic and-dynamic properties of novel insulin preparations, insulin administration forms, and antidiabetic drugs; Phase I-IV |
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2005 - 2009 |
Resident at the Department of Internal Medicine, St. Bernhard Hospital, Brake, Germany; Resident at the Department of Anesthesiology, Merheim Hospital, Cologne, Germany; Scientific Associate at the Institute for Pathology, University Hospital Cologne, Cologne, Germany |
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2005 |
Doctorate at the University of Cologne (Institute for Pathology, Prof. Dr. J. Thiele) |
