Get to know and reach out to the experts at Profil.
Dr. Eric Zijlstra
Executive Project Director
Eric has extensive experience in a range of topics and he is your contact partner, among others, for the following areas:
- Project development
- Medical technology
- Insulin pumps
- Glucose monitoring
- Alternative routes of insulin administration
- Exercise / Energy expenditure
Short Bio
With a background in Biomedical Engineering (Eindhoven University of Technology, The Netherlands), Eric Zijlstra started his career in the field of diabetes as a postgraduate researcher at the University of Birmingham (UK) in collaboration with AstraZeneca (Alderley Park, UK). Whilst at AstraZeneca Eric established stable isotope glucose tracer and indirect calorimetry methods in animal models of diabetes, and used these methods to conduct pre-clinical research on novel glucokinase activators.
In 2008 Eric joined Profil and has since worked on more than 80 clinical trials, investigating a large variety of diabetes drugs and medical devices in development. On the drug side, his main interest lies with novel insulin formulations, from faster-acting to ultra long-acting and their oral, inhaled and intradermal administrations. On the device side, blood glucose monitoring and insulin application devices are of special interest.
Eric is currently a research scientist and expert in the field of diabetes technology, alternative route administrations of insulin and glucose clamp studies. In his current role as Director Project Development / Medical Technology at Profil he leads a team of scientific consultants, oversees clinical trial design preparations and supports the dissemination of trial results at international diabetes conferences and scientific journals.
Publications
Here are Eric's recent publications:
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Eckstein ML. Boufleur Farinha J, McCarthy O, West DJ, Yardley JE, Bally L, Zueger T, Stettler C, Boff W, Reischak-Oliveira A, Riddell MC, Zaharieva DP, Pieber TR, Müller A, Birnbaumer P, Aziz F, Brugnara L, Haahr H, Zijlstra E, Heise T, Sourij H, Roden M, Hofmann P, Bracken RM, Pesta D, Moser O.
Differences in physiological responses to cardiopulmonary exercise testing in adults with and without type 1 diabetes: A pooled analysis.
DIABETES CARE 2020 Nov 12. doi: 10.2337/dc20-1496. Online ahead of print. -
Leohr J, Dellva MA, LaBell E, Coutant DE, Klein O, Plum-Moerschel L, Zijlstra E, Linnebjerg H.
Pharmacokinetic and glucodynamic responses of ultra rapid lispro vs lispro across a clinically relevant range of subcutaneous doses in healthy subjects.
Clin Ther 42: 1762-1777, 2020 -
Leohr J, Dellva MA, Coutant DE, LaBell E, Heise T, Andersen G, Zijlstra E, Hermanski L, Nosek L, Linnebjerg H.
Pharmacokinetics and glucodynamics of ultra rapid lispro (URLi) versus Humalog (lispro) in patients with type 2 diabetes mellitus: A phase I randomised, crossover study.
Clin Pharmacokinet 2020 May 29. doi: 10.1007/s40262-020-00901-2. Online ahead of print - Suico JG, Hövelmann U, Zhang S, Shen T, Bergman B, Sherr J, Zijlstra E, Frier BM, Plum-Mörschel L.
Glucagon administration by nasal and intramuscular routes in adults with type 1 diabetes during insulin-induced hypoglycaemia: A randomised, open-label, crossover study.
DIABETES THER 2020 Jun 8. doi: 10.1007/s13300-020-00845-7. Online ahead of print - Heise T, Linnebjerg H, Coutant D, LaBell E, Zijlstra E, Kapitza C, Bue-Valleskey J, Zhang Q, Dellva MA, Leohr J.
Ultra rapid lispro lowers postprandial glucose and more closely matches normal physiological glucose response compared to other rapid insulin analogs: A Phase 1 randomized, crossover study.
DIABETES OBES METAB 2020 May 21. doi: 10.1111/dom.14094. Online ahead of print - Halberg IB, Lyby K, Wassermann K, Heise T, Plum-Mörschel L, Zijlstra E.
The effect of food intake on the pharmacokinetics of oral basal insulin: A randomised crossover trial in healthy male subjects.
CLIN PHARMACOKINET 2019 May 16. doi: 10.1007/s40262-019-00772-2. (Epub ahead of print) - Halberg IB, Lyby K, Wassermann K, Heise T, Zijlstra E, Plum-Mörschel L.
Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial.
LANCET DIABETES ENDOCRINOL 2019 Jan 21. doi: 10.1016/S2213-8587(18)30372-3. (Epub ahead of print) -
Moser O, Eckstein ML, McCarthy O, Deere R, Bain SC, Haahr HL, Zijlstra E, Heise T, Bracken RM.PLOS ONE 2018 Apr 2. doi: 10.1371/journal.pone.0194750. eCollection 2018.
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Zijlstra E.J DIABETES SCI TECHNOL 2018 Apr 1. doi: 10.1177/1932296818767940. (Epub ahead of print)
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Zijlstra E, Coester HV, Heise T, Plum-Mörschel L, Rasmussen O, Rikte T, Pedersen LK, Qvist M, Sparre T.Injecting without pressing a button: An explanatory study of a shield-triggered injection mechanism.DIABETES OBES METAB 2017 Dec 27. doi: 10.1111/dom.13203. (Epub ahead of print)
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Moser O, Eckstein ML, McCarthy O, Deere R, Bain SC, Haahr HL, Zijlstra E, Bracken RM.Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes.DIABETOLOGY & METABOLIC SYNDROME 2017, 9:93. DOI: 10.1186/s13098-017-0294-1
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Zijlstra E, Jahnke J, Fischer A, Kapitza C, Forst T.J DIABETES SCI TECHNOL 2017 Oct 1. doi: 10.1177/1932296817735121. (Epub ahead of print)
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Zijlstra E, Demissie M, Graungaard T, Heise T, Nosek L, Bode B.J DIABETES SCI TECHNOL 2018; 12: 145-151
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Forst T, Zijlstra E.Glukoseselbstmessung - technische Möglichkeiten und Limitationen.Diabetologie 11: 51-50, 2016
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Heise T, Stender-Petersen K, Hövelmann U, Jacobsen JB, Nosek L, Zijlstra E, Haahr H.CLIN PHARMACOKINET 2016 Nov 22. doi: 10.1007/s40262-016-0473-5. (Epub ahead of print)
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Heise T, Hövelmann U, Zijlstra E, Stender-Petersen K, Jacobsen JB, Haahr H.DRUGS AGING 34 (1): 29-38, 2017
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Heise T, Zijlstra E, Nosek L, Rikte T, Haahr H.DIABETES OBES METAB 19: 208-215, 2017
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Zijlstra E, Heinemann L, Fischer A, Kapitza C.J DIABETES SCI TECHNOL 10: 1316-1323, 2016.
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Heise T, Zijlstra E, Nosek L, Heckermann S, Plum-Mörschel L, Forst T.DIABETES OBES METAB 18: 972-982, 2016
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Heinemann L, Zijlstra E, Pleus S, Freckmann G.DIABETES CARE 38: e139-e140, 2015
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Heise T. Bain SC, Bracken RM, Zijlstra E, Nosek L, Stender-Petersen K, Rabol R, Rowe E, Haahr HL.
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Greiner H, Schaller-Ammann R, Huber A, O’Connell M, Krejci J, Porro G, Korsatko S, Gurban J, Deller S, Brunner M, Berghofer A, Priedl J, Zijlstra E, Heise T, Pieber TR, Schaupp L.Continuous blood glucose monitoring (Cgm) system based on intravenous microdialysis and glucose sensing.
BIOMED TECH (Berl). 2013 Sep 7.doi:pii: /j/bmte.2013.58.issue-s1-l/bmt-2013-4224/bmt-2013-4224.xml. doi: 10.1515/bmt-2013-4224. [Epub ahead of print] -
Zijlstra E, Heise T, Nosek L, Heinemann L, Heckermann S.Continuous glucose monitoring: quality of hypoglycaemia detection.
DIABETES OBES METAB 15(2):130-135, 2013
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